Boston and Maine Railroad Depot may refer to:

• Contoocook Railroad Depot, Contoocook, NH, listed on the NRHP in New Hampshire
• Ely Railroad Depot, Fairlee, VT, listed on the NRHP in Vermont
• Raymond Railroad Depot, Raymond, NH, listed on the NRHP in New Hampshire
• Reading Railroad Depot, Reading, Massachusetts, listed on the NRHP in Massachusetts
• Stoneham Railroad Depot, Stoneham, Massachusetts, listed on the NRHP in Massachusetts