Book of Secrets may refer to:

• Books of secrets, compilations of technical and medicinal recipes and magic formulae, published in the 16th–18th centuries
• Book of Secrets, another name for the Grand Albert
• Book of Mysteries, also known as The Book of Secrets, a 1st-century BCE Essene text found among the Dead Sea Scrolls
• Book of Mysteries (Manichaeism), also known as The Book of Secrets, a 3rd-century religious text, one of the Seven Scriptures of Manichaeism
• The Book of Secrets (novel), 1994 novel by M. G. Vassanji
• Sefer HaRazim (The Book of Secrets), a Jewish mystical text
• The Book of Secrets, 1974 book series by Rajneesh
• Ketabe Serr (The Book of Secrets), by Muhammad ibn Zakariya al-Razi (9th–10th centuries)

• Book of Secrets (album), 1998 album by Balance of Power
• The Book of Secrets (album), 1997 album by Loreena McKennitt
• The Secret Book, 2006 Macedonian detective film directed by Vlado Cvetanovski
• National Treasure: Book of Secrets, 2007 film directed by Jon Turteltaub
• America's Book of Secrets, a program broadcast by History TV channel
• "Book of Secrets" (L.A.'s Finest), a 2019 television episode

• Liber Secretorum (disambiguation)