BoJack initially struggles with rehab, but finds the motivation to excel when he learns that Sarah Lynn once was a patient in the same clinic. He accidentally helps teenage patient Jamison sneak out to go to a party and follows her out of guilt, eventually finding her at her father's house, who she claims neglects her in favor of his new child. As BoJack helps her smash up the house, her father arrives and she tries to blame it on BoJack. Her father sees through the ruse and explains that the baby is actually Jamison's, taking them both back to rehab. BoJack catches Jamison trying to sneak a water bottle full of vodka in and takes it from her. Throughout the episode, a series of flashbacks are shown in reverse chronological order, all of them involving BoJack and alcohol, revealing that the first time he drank was as a young child following a house party thrown by his parents.

Princess Carolyn's still unnamed baby cries constantly, depriving of her sleep and making her more sluggish in day-to-day life. She orders a re-edit of Mr. Peanutbutter's movie Birthday Dad when questioned on how feminist her works are, which cuts it down to forty minutes and gets the movie cancelled. Todd, watching the baby, accidentally orders a TV show under its name, which Princess Carolyn realizes is the perfect opportunity to pitch Birthday Dad as a television show. She has an earnest talk with Vanessa Gekko and confides that she is afraid she may not properly love her daughter, but Gekko assures her that she just needs to keep going regardless and that it will come naturally. Princess Carolyn finally gets the baby to sleep, and decides that she will name her "Ruthie".

Diane travels the country filming journalistic videos with her bison cameraman Guy, who she begins to develop an intimate relationship with. Their boss asking them to find more "feel-good stories" in Guy's hometown of Chicago leads them to uncover a conspiracy involving massive conglomerate Whitewhale, but their company is bought out by it and the story is not enough to expose them. Diane and Guy argue when he is unable to introduce her as anything more than his coworker, and she leaves Chicago for Los Angeles after she tells him he cannot be the only good thing in her life. She returns home to find several letters from BoJack written in rehab, where he laments wasting years being depressed when he could have been happy, inspiring her to call Guy and offer to stay with him in Chicago.

Mr. Peanutbutter's and Pickles' friends set up a surprise party at their house to celebrate their upcoming marriage, only for him to reveal that he cheated on her just as they get home, forcing the guests to stay hidden. As they argue, Princess Carolyn loses Ruthie and Todd finds her, inspiring her to hire him as a nanny. Diane tells BoJack that she is moving to Chicago, and he promises that he will be fine without her when she asks. Pickles is devastated by the news, even more so when she learns that Mr. Peanutbutter cheated with Diane. Unable to decide what to do, she settles on forgiving him on the condition that she gets to sleep with someone else as comeuppance.

In a flashback, Sarah Lynn accidentally drinks vodka on the set of Horsin' Around, and BoJack blames hairstylist Sharona despite not knowing whose alcohol she drank. Rehab therapy horse Doctor Champ proclaims BoJack ready to leave after six months, but an angry BoJack stays after learning they are just clearing him out to make room for celebrity Joey Pogo. Ruthie takes up all of Todd's time, so he hires several assistants to do his jobs for him, one of which visits BoJack in rehab, where he reveals he held onto Jamison's vodka because it reminded him of the incident with Sarah Lynn. As he unintentionally inspires the assistant to start an uprising, he throws the bottle away, only for it to end up in Doctor Champ's hands and ruin his sobriety. Mr. Peanutbutter is hated after being outed as cheating on Pickles, but Princess Carolyn wins him the public's love back by pushing him in front of a car and claiming it was a suicide attempt. Diane calls Princess Carolyn and gets a deal to write her book of essays in six months, but struggles to start.

Todd's stepfather Jorge visits to inform him that his estranged mother needs a kidney, but he has already sold it to Whitewhale. They travel to Chicago and break into the center with Diane's help, retrieving the kidney while Jorge reveals to Todd that it was his mother who kicked him out and cut off contact, not himself. Hollywoo falls into chaos with all the assistants on strike, and Princess Carolyn and Lenny Turtletaub shut it down by promoting the leaders, and destroying the union. However, Princess Carolyn remembers her life as an assistant and decides to actually make a difference, enlisting the aid of Judah to help the assistants. BoJack leaves rehab but finds Doctor Champ at a bar, where he points out that BoJack has no horses in his life except Hollyhock because they all remind him of his parents, and BoJack checks him into another rehab facility when he continues to drink. Doctor Champ, blaming BoJack for his loss of sobriety, bitterly warns him that he destroys anyone who cares about him, and BoJack decides to finally go home.

Mr. Peanutbutter goes on tour with Joey Pogo as America's "face of depression" to spread awareness. Uncomfortable in his house, BoJack flies to Chicago to thank a depressed Diane for never giving up on him, and sees that Guy's house is a mess with him gone for a job, encouraging her to follow Guy's advice and take antidepressants. He goes to Wesleyan to see Hollyhock, where he learns that a job as a drama teacher is open. Returning to Los Angeles, he asks Princess Carolyn to give him a reference for the job while encouraging her to take time off and spend it with Ruthie. Attending an Alcoholics Anonymous meeting, he bumps into Sharona, who he apologizes to in earnest and is forgiven. She cuts his hair short, revealing he has been dyeing it black, and he chooses to wear it in its natural gray. He learns that he got the job, informing rabbit airport Cinnabon worker Maude of Emily's dating app when he realizes she may be asexual, and she matches with Todd. BoJack stops in Washington, D.C. and encounters Mr. Peanutbutter, deciding to finally give him a reenactment of a crossover episode between Horsin' Around and Mr. Peanutbutter's show. Princess Carolyn hires Judah to be her company's COO, while Diane starts taking antidepressants and gains weight upon Guy's return, which he is happy about. BoJack visits an Old English horse village tourist attraction, where he attends a church service and seems to find peace.

Margo Martindale, now a devoted nun, asks if she can truly be forgiven for her sins and steals the monsignor's car when she gets no solid answer. After being fired from Secretariat, Kelsey struggles to find work as a director but is tapped by her agent Rutabaga Rabitowitz to direct a female superhero movie. Put off by the banal, by-the-numbers pitch, she counters with her own hypothetical pitch, which gets her the job. Gina, filming a new movie, panics on set when her costar puts his hand on her neck and storms out in the middle of shooting. The director of the film almost recommends Gina for the lead in Kelsey's movie, but finds her to be "difficult" and instead posits Courtney Portnoy. Reporters Maximillian Banks and pig Paige Sinclair investigate the Sarah Lynn story, realizing somebody was with her in a voicemail she left for her mother before her death. They investigate her AA meeting place, where one member recalls BoJack telling a story about Penny, leading them to drive to New Mexico. Hollyhock goes to a party in New York City, where she has an anxiety attack while watching drunk people losing control of their bodies until a partygoer notices and takes her outside for air. He tells her a story about BoJack taking him and his friends to prom and his girlfriend getting alcohol poisoning, revealing him to be Penny's friend Pete from New Mexico, and reveals BoJack's name when Hollyhock asks.

Note: Aside from the title sequence, none of the main characters appear in this episode. BoJack is only indirectly mentioned by both Sarah Lynn and Peter.

BoJack sells his restaurant and Mr. Peanutbutter buys it. BoJack begins teaching, but finds his students to be below average and tries his best to encourage them, despite the fact that some of them start to show up to his AA meetings in character in an attempt to impress him. He attempts to get involved in Hollyhock's love of rugby, which only puts her off. She does not show up on the night of his students' acting showcase and he confronts her, and she admits she feels uncomfortable with how he moved in without asking and tried to get involved in her interests. BoJack returns to the showcase and gets a call from Charlotte just as it ends, who claims reporters are talking to Penny and warns him to figure out what is happening, causing him to have an anxiety attack.

Diane finds herself struggling to write about her personal traumas while on antidepressants, unintentionally starting a girl detective book based on a mall worker she met. She goes off her medication in an attempt to write better, but she only has a breakdown, forcing Guy to send the detective story to Princess Carolyn so Diane does not miss her deadline. Princess Carolyn loves the book, and after a conversation with her, Diane decides she would rather continue writing it. Sinclair and Banks track down Penny and try to ask her about BoJack, but Charlotte steps in and stops them from getting too much information, wanting Penny to take time to think about talking to them. She calls BoJack, and Todd finds him collapsed after the call.

Mr. Peanutbutter, Pickles, and Joey open the new restaurant and attempt to run it together, with Pickles and Joey disliking each other despite Mr. Peanutbutter attempting to get them to sleep together. They do, and discover they have feelings for each other as Pickles leaves with Joey for his upcoming tour. Sinclair and Banks ask Mr. Peanutbutter about seeing BoJack at his house during his bender with Sarah Lynn, which he confirms, as well as unintentionally revealing that he and Sarah Lynn had heroin with them. BoJack, Diane, Princess Carolyn, and Todd hole up in his office to determine what the story being run on him is, which they discover is Sarah Lynn when Sinclair calls Diane. BoJack expresses anger at being grilled after he has changed for the better, causing Todd to leave, and while Princess Carolyn plans to help him beat the story, Diane insists he should be honest and leaves in disgust when he lies to Sinclair on the phone. He asks Princess Carolyn why she is helping him after everything, and she says it is because she has loved him longer than she has loved anyone else.

BoJack does an interview with Biscuits Braxby about Sarah Lynn after Sinclair's story releases, and wins the public's love back as Biscuits softballs him. Confident, he agrees to do a second interview to boost the network's ratings, before which Biscuits talks to Sinclair and Doctor Champ, the latter of whom divulges BoJack's secrets out of spite. During the second interview, she reveals that BoJack waited seventeen minutes to call an ambulance after Sarah Lynn overdosed, and points out his disturbing pattern of abusing his power over young, impressionable women. Princess Carolyn chooses not to watch the interview, as does Todd, now dating Maude, who asks him to get an apartment with her. Diane meets Guy's son, who she chafes with, and watches the interview, disturbed by what she sees. While BoJack waits for the interview to air, he goes to a comedy club where he performed standup after Herb invited him to do a screen test for Horsin' Around and does a routine.

A few months after the second interview airs, BoJack is nationally hated, he has been fired from Wesleyan, and Hollyhock is not returning his calls. His accountant sells his house to pay off a lawsuit, forcing him to move in with Mr. Peanutbutter, and he receives a letter from Hollyhock that he is too afraid to open. Vance Waggoner offers BoJack his support after he is forced to take a job as an extra on Birthday Dad and BoJack accepts, the two of them coming up with an anti-PC "Horny Unicorn" character for BoJack to play in a movie. Waggoner takes him to EWESC to berate his estranged daughter, where BoJack is accepted by a misogynistic fraternity that invites him to a party. BoJack decides to open Hollyhock's letter, and the unseen contents make him drop it on the ground and sit in silence in the middle of the party as someone places a drink in his hand. Todd invites Jorge and his mother to a housewarming party at his new apartment and puts together a crew of actors to make the party look populated, but his mother does not show up. After the completion of Diane's book, Guy's son reads it and offers her notes.

Todd and Maude have dinner with Jorge, but his mother, wracked with guilt over kicking him out, refuses to join them. Hurt, Todd has Margo Martindale stage a hostage situation so he gets the chance to see her again, but she ends up having an anxiety attack and they reconnect in the hospital. As Guy asks Diane to move to Houston with him, she calls Mr. Peanutbutter after learning he has written a memoir. He apologizes for the ways he was thoughtless in their marriage and affirms that he is glad they were in each other's lives, as they helped each other become who they are today. Princess Carolyn gets an offer from Lenny Turtletaub to operate a new wing of his agency while she learns that Judah is playing a show with his band, which she attends but finds he did not show up. She finds him at the office doing work and he encourages her to forge her own path instead of working under Turtletaub, and confesses his love for her through a song he was supposed to play. BoJack, having ended his sobriety, gets a call from Angela Diaz, the former president of ABC and the woman who fired Herb, and he goes to her house to find that she had a Horsin' Around Blu-ray produced. She explains that she wants BoJack to authorize a re-edit of Horsin' Around in which he is not present and she reveals after he signs a contract that he could have gotten away with keeping Herb on the show, to his fury. He steals her car and a Blu-ray, and gets drunk as he drives to his old house. He breaks in and watches the Horsin' Around screen test while continuing to drink.

BoJack awakens in a recurring dream of his, where he goes to a dinner party at Beatrice's house and eats with other dead people, including Herb, Sarah Lynn, Crackerjack, and Butterscotch in Secretariat's body. They discuss the best and worst parts of their life before going into a theatre, at which point BoJack claims his dream usually ends, but it continues. As the attendees all perform acts that relate to their lives before being sucked into a black doorway, BoJack's father pulls him aside for a smoke and expresses his regrets about their relationship, before revealing BoJack is actually drowning in his pool. As the rest of the attendees vanish into the doorway, black tar emerges from it and starts to chase BoJack through the house. Remembering that he called Diane before the dream started, he assumes that he cannot be dying, and so he tries to call her again. She points out that nothing that is happening is real and she never picked up the phone, and so he accepts his fate as he asks how her day was.

BoJack is found by the new owners of his old house and sentenced to fourteen months in prison for breaking and entering, where he begins staging theatrical productions with the inmates. He is allowed one day of release for Princess Carolyn and Judah's wedding, and is taken by Mr. Peanutbutter, who finally replaces the "D" on the Hollywood Sign but accidentally replaces it with a "B". He reveals to BoJack that he has been going to therapy and has broken his cycle of forcing himself into relationships. Todd takes BoJack for a walk on the beach when he gets to the wedding and tells him that he is finally forming a relationship with his mother, and that all he had to do was strive to make the change he wanted. BoJack dances with Princess Carolyn as they reminisce on what he would do if she did not want to get married, and she promises to help him find a good agent if he decides to return to the industry. He finds Diane on the roof, where she reveals he left her a drunken voicemail the night he tried to commit suicide blaming her for not picking up the phone, and that it almost ended her relationship with Guy, but she instead moved to Houston and married him. As they acknowledge that this will likely be their last conversation, BoJack tells her a story from prison which ended with him unhappy, and muses that the point of life is that it is hard and then you die. Diane counters that the point is that it is hard and then you keep living. They agree that it is a nice night and look up at the stars together.