Blume may refer to:

• Blume (band), an Italian band

• Anna and Bernhard Blume, German artistic photographers
• Astrid Blume (1872–1924), Danish educator and temperance advocate
• Bianka Blume (1843–1896), German opera singer
• Brian Blume (born 1950), a business partner of Gary Gygax in TSR, Inc., producers of the fantasy role-playing game, Dungeons & Dragons
• Carl Ludwig Blume (1796–1862), a German-Dutch botanist, whose botanical abbreviation is Blume
• Clemens Blume (1862–1932), a Jesuit hymnologist
• Clint Blume (1898–1973), a Major League Baseball player
• Danny Blume (born 1960), an American music producer, musician and composer
• David Blume, an American permaculture teacher and entrepreneur
• Fred H. Blume (1875–1971), a Justice of the Wyoming Supreme Court
• Friedrich Blume (1893–1975), a German professor of musicology in Kiel University
• Georg Blume, a correspondent in Beijing, China of the German newspapers "Die Zeit" and "taz"
• Heinrich Blume, German politician
• Holger Blume (born 1973), a German sprinter
• Joaquín Blume (1933–1959), a Spanish gymnast
• John Blume (1909–2002), an American structural engineer
• Judy Blume (born 1938), an American author
• Lawrence E. Blume, an American professor of economics
• Lesley M. M. Blume, an author, journalist, columnist and cultural observer based in New York City
• Marc Blume (born 1973), a German sprinter
• Marco Blume, a German professional Magic: The Gathering player
• Markus Blume (born 1975), a German politician
• Pernille Blume (born 1994), a Danish swimmer and Olympic gold medalist
• Peter Blume (1906–1992), an American painter and sculptor
• Ray Blume (born 1958), a retired American basketball player
• Renate Blume (born 1944), a German actress
• Ricardo Blume (born 1933), a Peruvian actor and theater director
• Robert Blume (1868–1937), an American sailor serving in the United States Navy during the Spanish–American War who received the Medal of Honor for his actions
• Thaïs Blume (born 1984), Spanish actress
• Veronica Blume (born 1977), a Spanish fashion model and actress
• Walter Blume (disambiguation)

• Blume (Organization), a fictional organization, which appears in Watch Dogs, Watch Dogs 2, and Watch Dogs: Legion.

• Blume Bl.502, a family of four-seat light aircraft designed in West Germany by Dr Walter Blume in the late 1950s
• Blume High School, a historic building in downtown Wapakoneta, Ohio, United States
• Blume in Love, a 1973 film written and directed by Paul Mazursky
• Desert Blume, Alberta, a hamlet in Canada
• Blum (disambiguation)
• Bloom (disambiguation)
• Bluma (disambiguation)