Big One, or The Big One may refer to:

• The Big One (earthquake), describing an anticipated megathrust earthquake along Western North America or Japan
• The Big One (Philippines), describing another anticipated earthquake along the West Valley Fault in Luzon

• The Big One, a 1995 TV film starring Rik Mayall
• The Big One (film), a 1998 film by Michael Moore
• The Big One, a 2005 film starring Yangzom Brauen
• The Big One: the Story of TGR's 16 Years in Jackson Hole, a 2006 ski documentary by Teton Gravity Research
• The Big One (TV series), an early-1990s comedy series starring Sandi Toksvig and Mike McShane
• "The Big One" (Gilmore Girls), a third-season episode of the television series Gilmore Girls
• "The Big One" (Dexter), a 2010 episode of the television series Dexter
• The Big One: The Great Los Angeles Earthquake, a 1990 made-for-television movie starring Joanna Kerns, depicting a massive earthquake that destroys Los Angeles, California
• Sōkichi Bamba/Big One, a fictional character in J.A.K.Q. Dengekitai
• "The Big One", the fake heart attack that Redd Foxx would regularly have on the television series Sanford and Son
• Big One, a locomotive from the anime series The Galaxy Railways
• The Big One (roller coaster), a roller coaster in Blackpool Pleasure Beach
• "The Big One", the nickname given to Red Nose Day 2007, a fundraising event held in the UK organised by Comic Relief
• "The Big One", a slogan used by WLW 700 AM, a radio station in Cincinnati, Ohio
• The Big One (NASCAR), phrase describing any crash usually involving five or more cars in NASCAR and ARCA stock car racing
• Big One for One Drop, a poker tournament featuring the largest buy-in events
• ”The Big One”, nickname of the Big Score, the final heist mission in Grand Theft Auto V.
• The Big One, a 2023 protest by activist group Extinction Rebellion
• The "B1G ONE", an international Pump It Up tournament, endorsed by Andamiro Korean gaming company.

• “The Big One” — World War II

• The Big One (Daddy Freddy album), a 1994 album by ragga vocalist Daddy Freddy
• Big Ones (Aerosmith album), a 1994 compilation album by Aerosmith
• Big Ones (Loverboy album), a 1989 compilation album by Loverboy

• "Big One", single by Judge Dread, Lemon, Hughes 1973
• "The Big One" (George Strait song), 1994
• The Big One (Black song), 1988
• "The Big One", a song by Nellie McKay from her album Pretty Little Head
• "The Big One", a 1998 single by Confederate Railroad
• "The Big One", an instrumental theme by Alan Tew used in The People's Court TV show

• Little One (disambiguation)
• Big Two (disambiguation)
• Big Three (disambiguation)
• Big Four (disambiguation)
• Big Five (disambiguation)
• Big Six (disambiguation)
• Big Seven (disambiguation)
• Big Eight (disambiguation)
• Big Ten (disambiguation)
• Big 12