Berkley is a surname. Notable people with the surname include:

• Austin Berkley (born 1973), former English professional footballer
• Elizabeth Berkley (born 1972), American TV and film actress
• George Berkley (engineer) (died 1893), British civil engineer
• Richard L. Berkley (born 1931), mayor of Kansas City, Missouri (1979–1991)
• Robyn Berkley, fashion publicist
• Seth Berkley (born 1956), American epidemiologist
• Shelley Berkley (born 1951), U.S. Congresswoman
• Theresa Berkley (died 1836), 19th century London dominatrix
• W.R. Berkley (born 1946), Insurance Tycoon. Founder for W. R. Berkley Corporation