Protein-coding gene in the species Homo sapiens
Breast cancer metastasis suppressor 1protein that in humans is encoded by the BRMS1 gene .[ 5] [ 6]
This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines .[ 7] nucleus , and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms .[ 6]
References
External links
Further reading
Meehan WJ, Welch DR (2003). "Breast cancer metastasis suppressor 1: update". Clin. Exp. Metastasis . 20 (1): 45– 50. doi :10.1023/A:1022542519586 . PMID 12650606 . S2CID 26142383 . Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Res. 6 (9): 791– 806. doi :10.1101/gr.6.9.791 PMID 8889548 . Samant RS, Debies MT, Shevde LA, et al. (2002). "Identification and characterization of the murine ortholog (brms1) of breast-cancer metastasis suppressor 1 (BRMS1)" . Int. J. Cancer 97 (1): 15– 20. doi :10.1002/ijc.1569 PMID 11774238 . S2CID 19747938 . Shevde LA, Samant RS, Goldberg SF, et al. (2002). "Suppression of human melanoma metastasis by the metastasis suppressor gene, BRMS1". Exp. Cell Res. 273 (2): 229– 39. doi :10.1006/excr.2001.5452 . PMID 11822878 . Janneau JL, Maldonado-Estrada J, Tachdjian G, et al. (2002). "Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells" . J. Clin. Endocrinol. Metab. 87 (11): 5336– 9. doi :10.1210/jc.2002-021093 PMID 12414911 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899– 903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Meehan WJ, Samant RS, Hopper JE, et al. (2004). "Breast cancer metastasis suppressor 1 (BRMS1) forms complexes with retinoblastoma-binding protein 1 (RBP1) and the mSin3 histone deacetylase complex and represses transcription" . J. Biol. Chem. 279 (2): 1562– 9. doi :10.1074/jbc.M307969200 PMID 14581478 . Cicek M, Samant RS, Kinter M, et al. (2004). "Identification of metastasis-associated proteins through protein analysis of metastatic MDA-MB-435 and metastasis-suppressed BRMS1 transfected-MDA-MB-435 cells". Clin. Exp. Metastasis . 21 (2): 149– 57. doi :10.1023/B:CLIN.0000024729.19084.f0 . PMID 15168732 . S2CID 19383717 . Nikolaev AY, Papanikolaou NA, Li M, et al. (2004). "Identification of a novel BRMS1-homologue protein p40 as a component of the mSin3A/p33(ING1b)/HDAC1 deacetylase complex". Biochem. Biophys. Res. Commun. 323 (4): 1216– 22. doi :10.1016/j.bbrc.2004.08.227 . PMID 15451426 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121– 7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Stark AM, Tongers K, Maass N, et al. (2005). "Reduced metastasis-suppressor gene mRNA-expression in breast cancer brain metastases". J. Cancer Res. Clin. Oncol. 131 (3): 191– 8. doi :10.1007/s00432-004-0629-9 . PMID 15592684 . S2CID 12411341 . DeWald DB, Torabinejad J, Samant RS, et al. (2005). "Metastasis suppression by breast cancer metastasis suppressor 1 involves reduction of phosphoinositide signaling in MDA-MB-435 breast carcinoma cells" . Cancer Res . 65 (3): 713– 7. doi :10.1158/0008-5472.713.65.3 PMID 15705865 . S2CID 24886361 . Cicek M, Fukuyama R, Welch DR, et al. (2005). "Breast cancer metastasis suppressor 1 inhibits gene expression by targeting nuclear factor-kappaB activity" . Cancer Res . 65 (9): 3586– 95. doi :10.1158/0008-5472.CAN-04-3139 PMID 15867352 . Hurst DR, Mehta A, Moore BP, et al. (2006). "Breast cancer metastasis suppressor 1 (BRMS1) is stabilized by the Hsp90 chaperone" . Biochem. Biophys. Res. Commun . 348 (4): 1429– 35. doi :10.1016/j.bbrc.2006.08.005 . PMC 1557677 PMID 16919237 . Samant RS, Clark DW, Fillmore RA, et al. (2007). "Breast cancer metastasis suppressor 1 (BRMS1) inhibits osteopontin transcription by abrogating NF-κB activation" . Mol. Cancer . 6 : 6. doi :10.1186/1476-4598-6-6 PMC 1796551 PMID 17227585 . Rivera J, Megias D, Bravo J (2007). "Proteomics-based strategy to delineate the molecular mechanisms of the metastasis suppressor gene BRMS1". J. Proteome Res. 6 (10): 4006– 18. doi :10.1021/pr0703167 . PMID 17854218 .
