Asclepiades of Antioch (Greek: Ἀσκληπιάδης, also: Aslipiades or Askelpiades - † around 218) called the Confessor, was Patriarch of Antioch from 211 until his death. He succeeded Serapion as Patriarch of Antioch in 211. He was given the title of martyr, due to the trials he endured during Roman persecution.^[1]

Eusebius of Caesarea states that his term of office began in the first year of Caracalla's reign, so that 212 is usually given as the year in which Asclepiades took office. Harnack, referring to another source, suspects a somewhat earlier start. In addition to the year 218, the year of his death is also given as 220. Asclepiades took office from his predecessor Serapion. His successor was Philetus.

A full-body relic of Asclepiades is kept in Austria, in the Church of the Redemeer, Vienna [de]

His memorial day in the Roman Catholic Church is kept on 18 October.

• Paul of Samosata