Antigonus or Antigonos (Ancient Greek: Ἀντίγονος), a Greek name meaning "comparable to his father" or "worthy of his father", may refer to:

• Three Macedonian kings of the Antigonid dynasty that succeeded Alexander the Great:
  • Antigonus I Monophthalmus (382–301 BC)
  • Antigonus II Gonatas (319–239 BC)
  • Antigonus III Doson (263–221 BC)
    • Antigonus, son of Echecrates, the nephew of Antigonus III Doson
• Antigonus II Mattathias (died 37 BC), last ruler of the Hasmonean kingdom of Judea

• Antigonus (Seleucid admiral), son of Menophilus, Seleucid admiral of the mid-2nd century BC
• Antigonus, a general of King Perseus in the Third Macedonian War, was sent to Aenia to guard the coast

• Antigonus (historian), Greek writer on history
• Antigonus of Alexandria, ancient Greek grammarian
• Antigonus of Carystus, 3rd century BC Greek writer on various subjects
• Antigonus of Cumae, ancient Greek writer on agriculture
• Antigonus of Sokho, Jewish scholar of the 3rd century BC
• Antigonus, writer on painting, mentioned by Diogenes Laërtius

• Antigonus (physician), an ancient Greek surgeon
• Antigonus (sculptor), a Greek sculptor of the 3rd century BC
• Antigonos (son of Callas), Macedonian hetairos and athlete of the late 4th century BC
• Antigonus (butterfly), a genus of skipper butterflies