Anthony or Tony Griffin may refer to:

• Anthony J. Griffin (1866–1935), U.S. Representative from New York
• Anthony C. Griffin, American plastic surgeon
• Anthony Griffin (Royal Navy officer) (1920–1996), Controller of the Royal Navy
• Anthony Griffin (rugby league) (born 1966), Australian rugby league football coach
• Anthony Griffin (footballer) (born 1979), retired English footballer
• Tony Griffin (hurler) (born 1981), Irish hurler
• Tony Griffin (athlete), British Paralympic athlete