Andrew Wylie may refer to:

• Andrew Wylie (footballer), manager of Reading Football Club, England between 1926 and 1931
• Andrew Wylie (college president) (1789–1851), first president of Indiana University
• Andrew Wylie (judge) (1814–1905), US federal judge
• Andrew Wylie (literary agent) (born 1947), agent for high-profile authors including Martin Amis, Salman Rushdie and Philip Roth
• Andrew Wylie (American football) (born 1994), American football offensive tackle
• Andrew Wylie (cricketer) (born 1971), South African cricketer
• Andrew Wylie (skier) (born 1961), British Olympic skier
• Sir Andrew Wylie, fictional protagonist of the novel Sir Andrew Wylie, of that Ilk (1822) by the novelist John Galt
• Sir Andrew Graham Wylie (born 1959), British businessman

• Andrew Wyllie (pathologist) (1944–2022), Scottish pathologist
• Andrew Wyllie (engineer) (born 1962), Scottish civil engineer
• Wylie (surname)