Afzal Khan may refer to:

• Afzal Khan (general) (died 1659), Bijapuri general
• Afzal Khan (actor) (born 1966), Pakistani actor
• Afzal Khan Shirazi, Mughal administrator and prime minister
• Mir Afzal Khan, former Pakistani politician
• Afzal Khan Lala (1926–2015), Pashtun nationalist
• Afzal Khan (British politician) (born 1958), UK Member of Parliament and former Member of the European Parliament
• Afzal Ahmed Khan, Indian film director and producer
• Afzal Rahman Khan (1921–2005), Pakistan Navy admiral and politician
• Afzal Khan Khattak, Pashtun chief of the Khattak tribe
• Afzal Kahn (automotive designer) (born 1964), British automotive designer
• Afzal H. Khan, Bangladesh politician