Adrian Smith may refer to:

• Adrian Smith (basketball) (born 1936), American basketball player
• Adrian Smith (architect) (born 1944), American architect
• Sir Adrian Smith (statistician) (born 1946), English statistician and academic
• Adrian Smith (musician) (born 1957), English musician, member of the band Iron Maiden
• Adrian Smith (strongman) (born 1964), British professional strongman competitor
• Adrian Smith (politician) (born 1970), United States representative from Nebraska's 3rd congressional district
• Adrian Smith (illustrator), British illustrator of game materials
• Adrian Smith (rugby union) (born 1987), New Zealand rugby player