AXP may refer to:

• Alpha AXP, later known as DEC Alpha, a 64-bit instruction set architecture developed by Digital Equipment Corporation (DEC)
• Anomalous X-ray pulsar
• American Express, whose NYSE ticker symbol is "AXP"
• Alexandra Parade railway station, United Kingdom, whose National Rail code is "AXP"
• Alpha Chi Rho, a fraternity whose Greek letters resemble "ΑΧΡ"
• Automotive X Prize
• The Atheist Experience
• Athlon XP, an AMD processor
• Architectural Experience Program
• Aerial Xpress, a pro wrestling tag team of Scorpio Sky and Quicksilver
• Spring Point Airport, whose IATA airport code is "AXP"