AUC may refer to:

• Ab urbe condita or Anno urbis conditae, Latin for "from the founding of the city" (of Rome), used for dates
• African Union Commission, the executive/administrative branch or secretariat of the supranational organisation
• Ammonium uranyl carbonate, a chemical compound used in uranium processing
• Appropriate use criteria for a medical procedure or service
• Area under the curve (receiver operating characteristic), a performance measure for binary classifiers
• Area under the curve (pharmacokinetics), regarding plasma drug concentration-time curves
• Authentication Center in a GSM mobile phone network
• United Self-Defense Forces of Colombia (Spanish: Autodefensas Unidas de Colombia), former Colombian paramilitary and drugs group
• Santiago Pérez Quiroz Airport, Arauca, Colombia, IATA code
• Analytical ultracentrifugation, Physical and biophysical chemistry instrument
• a codon for the amino acid isoleucine

• Aalborg University, formerly Aalborg University Center
• Alliance University College, merged into Ambrose University College, Calgary, Alberta, Canada
• Amsterdam University College, a liberal arts and sciences college in Amsterdam, Netherlands
• The American University in Cairo, Egypt
• American University of the Caribbean a medical school in Sint Maarten
• Apple University Consortium in Australia
• Atlanta University Center, the University Center Consortium in Atlanta, Georgia
• Atlantic Union College, a liberal arts college in South Lancaster, Massachusetts, US