APCO may refer to:

• Apco Aviation, an Israeli aircraft manufacturer
• APCO Worldwide, a public relations firm
• Air Pollution Control Officer
• Association of Public-Safety Communications Officials-International, an organization providing standards for telecommunications
• APCO radiotelephony spelling alphabet, a phonetic spelling alphabet
• Project 25, a modern public safety radio standard
• APCO-16, an older telecommunications standard
• APCO Oil Corporation, a defunct Oklahoma-based petroleum business
• Apco Keara, an Israeli-made paraglider
• Apco Fiesta, a family of paragliders
• Association of Pleasure Craft Operators (UK)
• APCO - Andhra Pradesh State Handloom Weavers Cooperative Society