60S ribosomal protein L8

RPL8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4CCM, 4CCN, 4CCO, 4UG0, 4V6X, 5AJ0, 4D67, 3J7Q, 4Y3O, 4UJC, 3J7R, 4D5Y, 4UJE, 4UJD, 3J7P, 3J7O, 3J92, 4V5Z
Identifiers
Aliases	RPL8, L8, ribosomal protein L8
External IDs	OMIM: 604177; MGI: 1350927; HomoloGene: 32141; GeneCards: RPL8; OMA:RPL8 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	144,792,587 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	76,790,514 bp
RNA expression pattern
	Top expressed in
	Top expressed in
	More reference expression data
	More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
	Sources:Amigo / QuickGO
Orthologs
	6132
	26961
	ENSG00000161016
	ENSMUSG00000003970
	P62917
	P62918
	NM_000973; NM_033301; NM_001317771; NM_001317782
	NM_012053
	NP_000964; NP_001304700; NP_001304711; NP_150644
	NP_036183
	Wikidata
View/Edit Human	View/Edit Mouse

60S ribosomal protein L8 is a protein that in humans is encoded by the RPL8 gene.^[5]^[6]^[7]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L2P family of ribosomal proteins. It is located in the cytoplasm. In rat, the protein associates with the 5.8S rRNA, very likely participates in the binding of aminoacyl-tRNA, and is a constituent of the elongation factor 2-binding site at the ribosomal subunit interface. Alternatively spliced transcript variants encoding the same protein exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000161016 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000003970 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hanes J, Klaudiny J, von der Kammer H, Scheit KH (Feb 1994). "Characterization by cDNA cloning of the mRNA of human ribosomal protein L8". Biochem Biophys Res Commun. 197 (3): 1223–8. doi:10.1006/bbrc.1993.2607. PMID 7506540.
^ Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
^ ^a ^b "Entrez Gene: RPL8 ribosomal protein L8".

Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
Uhlein M, Weglöhner W, Urlaub H, Wittmann-Liebold B (1998). "Functional implications of ribosomal protein L2 in protein biosynthesis as shown by in vivo replacement studies". Biochem. J. 331 (2): 423–30. doi:10.1042/bj3310423. PMC 1219371. PMID 9531480.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
Yoshihama M, Uechi T, Asakawa S, et al. (2002). "The human ribosomal protein genes: sequencing and comparative analysis of 73 genes". Genome Res. 12 (3): 379–90. doi:10.1101/gr.214202. PMC 155282. PMID 11875025.
Brezillon S, Lannoy V, Franssen JD, et al. (2003). "Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8". J. Biol. Chem. 278 (2): 776–83. doi:10.1074/jbc.M206396200. PMID 12401809.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Odintsova TI, Müller EC, Ivanov AV, et al. (2004). "Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing". J. Protein Chem. 22 (3): 249–58. doi:10.1023/A:1025068419698. PMID 12962325. S2CID 10710245.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.

External links

Overview of all the structural information available in the PDB for UniProt: P62917 (60S ribosomal protein L8) at the PDBe-KB.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000161016 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000003970 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7506540-5] Hanes J, Klaudiny J, von der Kammer H, Scheit KH (Feb 1994). "Characterization by cDNA cloning of the mRNA of human ribosomal protein L8". Biochem Biophys Res Commun. 197 (3): 1223–8. doi:10.1006/bbrc.1993.2607. PMID 7506540.

[pmid9582194-6] Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.

[entrez-7] "Entrez Gene: RPL8 ribosomal protein L8".

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[5]

[6]

[7]

Fahrer / Team für die Suche eingeben:

Fahrer / Team für die Suche eingeben:

Langbahn Team – Weltmeisterschaft

60S ribosomal protein L8

References

Further reading

External links