The 2010 Grambling State Tigers football team represented Grambling State University as a member of the Southwestern Athletic Conference (SWAC) during the 2010 NCAA Division I FCS football season. Led by fourth-year head coach Rod Broadway, the Tigers compiled an overall record of 9–2 and a mark of 8–1 in conference play, and finished as co-champion in the SWAC West Division.

Date	Opponent	Rank	Site	Result	Attendance	Source
September 4	vs. Louisiana Tech*		Independence Stadium Shreveport, LA (Port City Classic)	L 6–20	34,762	[1]
September 18	Jackson State		Eddie G. Robinson Memorial Stadium Grambling, LA	W 28–21	7,057	[2]
September 25	vs. Prairie View A&M		Cotton Bowl Dallas, TX (rivalry)	W 34–17		[3]
October 2	at Alabama A&M		Louis Crews Stadium Normal, AL	W 25–22	12,328	[4]
October 9	Alabama State		Eddie G. Robinson Memorial Stadium Grambling, LA	W 22–7		[5]
October 16	Alcorn State		Eddie G. Robinson Memorial Stadium Grambling, LA	W 38–28	6,980	[6]
October 23	at Mississippi Valley State		Charles Kerg Field Greenville, MS	W 35–14	3,197	[7][8]
October 30	vs. Arkansas–Pine Bluff	No. 23	War Memorial Stadium Little Rock, AR (Delta Classic)	W 35–25	29,373	[9]
November 6	Concordia (AL)*	No. 21	Eddie G. Robinson Memorial Stadium Grambling, LA	W 35–0	14,543	[10]
November 11	at Texas Southern	No. 20	Delmar Stadium Houston, TX	L 34–41 OT		[11]
November 27	vs. Southern	No. 23	Louisiana Superdome New Orleans, LA (Bayou Classic)	W 38–17	43,494	[12]
*Non-conference game Homecoming Rankings from The Sports Network Poll released prior to the game

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