The 2001 Pittsburgh Panthers football team represented the University of Pittsburgh in the 2001 NCAA Division I-A football season.

Date	Time	Opponent	Site	TV	Result	Attendance	Source
September 1	6:00 p.m.	East Tennessee State*	Heinz Field Pittsburgh, PA		W 31–0	47,919
September 8	1:30 p.m.	South Florida*	Heinz Field Pittsburgh, PA		L 26–35	39,542
September 27	8:00 p.m.	No. 1 Miami (FL)	Heinz Field Pittsburgh, PA	ESPN	L 21–43	57,224
October 6	2:30 p.m.	at Notre Dame*	Notre Dame Stadium Notre Dame, IN (rivalry)	NBC	L 7–24	80,795
October 13	12:00 p.m.	Syracuse	Heinz Field Pittsburgh, PA (rivalry)	ESPN Plus	L 10–42	52,367
October 20	12:00 p.m.	at Boston College	Alumni Stadium Chestnut Hill, MA	ESPN Plus	L 7–45	41,637
October 27	12:00 p.m.	at Temple	Veterans Stadium Philadelphia, PA		W 33–7	12,859
November 3	12:00 p.m.	No. 12 Virginia Tech	Heinz Field Pittsburgh, PA	ESPN Plus	W 38–7	55,585
November 10	1:30 p.m.	at Rutgers	Rutgers Stadium Piscataway, NJ		W 42–0	13,520
November 24	12:00 p.m.	at West Virginia	Mountaineer Field Morgantown, WV (Backyard Brawl)	ESPN	W 23–17	44,407
December 1	1:30 p.m.	UAB*	Heinz Field Pittsburgh, PA		W 24–6	40,855	[1]
December 20	7:30 p.m.	vs. NC State*	Florida Citrus Bowl Orlando, FL (Tangerine Bowl)	ESPN	W 34–19	28,562
*Non-conference game Homecoming Rankings from AP Poll released prior to the game All times are in Eastern time

^[2]

• The December 1 game against UAB was a makeup of games that were postponed due to the 9/11 terror attacks cancelling all major sporting events for one week.