The 1991 Prairie View A&M Panthers football team represented Prairie View A&M University as a member of the Southwestern Athletic Conference (SWAC) during the 1991 NCAA Division I-AA football season. Led by first-year head coach Ronald Beard, the Panthers compiled an overall record of 0–11, with a mark of 0–7 in conference play, and finished eighth in the SWAC.

Due to several handicaps, including not having any scholarships, Beard later referred to the team as a "intramural or club football" team.^[1]

Date	Time	Opponent	Site	Result	Attendance	Source
September 7	7:30 p.m.	at Texas Southern	Rice Stadium Houston, TX (Labor Day Classic)	L 6–23		[2]
September 14	7:30 p.m.	at Angelo State*	San Angelo Stadium San Angelo, TX	L 0–55		[3]
September 21	7:00 p.m.	at Southwest Missouri State*	Briggs Stadium Springfield, MO	L 0–61	11,835	[4]
September 28	7:30 p.m.	at Texas A&I*	Javelina Stadium Kingsville, TX	L 3–41		[5]
October 5	7:00 p.m.	at Grambling State	Eddie G. Robinson Memorial Stadium Grambling, LA (rivalry)	L 7–77	10,350	[6]
October 12	1:30 p.m.	Cameron*	Edward L. Blackshear Field Prairie View, TX	L 6–51		[7]
October 19	1:30 p.m.	at Alcorn State	Henderson Stadium Lorman, MS	L 0–61		[8]
October 26	1:30 p.m.	vs. No. 7 Alabama State	War Memorial Stadium Little Rock, AR (Arkansas Classic)	L 0–92		[9]
November 2	1:30 p.m.	Mississippi Valley State	Edward L. Blackshear Field Prairie View, TX	L 0–41		[10]
November 9	2:00 p.m.	at Southwest Texas State*	Bobcat Stadium San Marcos, TX	L 6–59		[11]
November 23	7:00 p.m.	at Southern	A. W. Mumford Stadium Baton Rouge, LA	L 20–56
*Non-conference game Homecoming Rankings from NCAA Division I-AA Football Committee Poll released prior to the game All times are in Central time

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