← 1980 1979 1978 1981 in Luxembourg → 1982 1983 1984
Decades:	1960s 1970s 1980s 1990s 2000s
See also:	History of Luxembourg List of years in Luxembourg

The following lists events that happened during 1981 in the Grand Duchy of Luxembourg.

• 6 January – Gaston Thorn takes up his post as President of the European Commission.^[2]
• 2 February – A new newspaper, Haut, is launched.
• 14 February – Hereditary Grand Duke Henri marries Maria Teresa Mestre.^[3]

• 4 April – Representing Luxembourg, Jean-Claude Pascal finishes eleventh in the Eurovision Song Contest 1981 with the song C'est Peut-Etre Pas L'Amerique.
• 23 April – Rights of confidentiality that patients enjoy with doctors are applied to bankers and clients to help promote Luxembourg as a financial centre.^[4]
• 14 June – The Soviet Union's Yuri Barinov wins the 1981 Tour de Luxembourg.

• 7 July – The European Parliament passes a resolution to 'review' the seat of the Secretariat being in Luxembourg City.^[5]
• 31 July – A Belgian fighter jet collides with the 285 m Dudelange Radio Tower, destroying the tower and killing a couple in a nearby house.
• 7 August – Luxembourg files an appeal with the European Court of Justice against the European Parliament's resolution of 7 July.
• 15 September – Christian Calmes is appointed Grand Marshal of Luxembourg.

• 10 October – Communal elections are held across Luxembourg.
• 31 December – Camille Polfer steps down as Mayor of Luxembourg City after only two years, due to ill health, and is succeeded by his daughter, Lydie the following day.

• 1 June – Tessy Scholtes, kareteka
• 16 September - Francesco Tristano Schlimé, pianist
• 11 November – Guillaume, Hereditary Grand Duke of Luxembourg

• 16 September – Émile Colling, politician

• Thewes, Guy (2006). Les gouvernements du Grand-Duché de Luxembourg depuis 1848 (PDF) (in French) (2006 ed.). Luxembourg City: Service Information et Presse. ISBN 978-2-87999-156-6. Retrieved 12 December 2009.