The 1966 Southern Jaguars football team was an American football team that represented Southern University as a member of the Southwestern Athletic Conference (SWAC) during the 1966 NCAA College Division football season. Led by Robert E. Smith in his second season as head coach, the Jaguars compiled an overall record of 6–2–1, with a mark of 4–2–1 in conference play, and finished as SWAC co-champion.

Date	Opponent	Site	Result	Attendance	Source
September 17	at Texas Southern	Jeppesen Stadium Houston, TX	L 14–20		[1]
September 24	Prairie View A&M	University Stadium Baton Rouge, LA	W 35–0	10,173	[2]
October 1	at Morris Brown*	Herndon Stadium Atlanta, GA	W 28–10		[3]
October 8	at Arkansas AM&N	Pumphrey Stadium Pine Bluff, AR	W 28–14		[4]
October 15	Jackson State	University Stadium Baton Rouge, LA (rivalry)	W 45–28	6,758–10,219	[5][6]
October 22	at Alcorn A&M	Henderson Stadium Lorman, MS	T 14–14	5,200	[7][8]
October 29	at No. 6 Tennessee A&I*	Hale Stadium Nashville, TN	L 9–31		[9]
November 5	Wiley	University Stadium Baton Rouge, LA	W 27–0	11,528	[10]
November 12	Florida A&M*	University Stadium Baton Rouge, LA	W 17–13		[11]
November 19	at Grambling	University Stadium Baton Rouge, LA (rivalry)	W 41–13		[12]
*Non-conference game Homecoming Rankings from AP Poll released prior to the game

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