The 1926 Louisville Colonels season was their fourth and final season in the league and only season as the Colonels. Re-entering the NFL for the first time since the 1923 NFL season when they participated as the Louisville Brecks, the Colonels played four games and suffered shutout losses each time.

The 1926 Colonels suffered a 47–0 whitewashing at the hands of the Detroit Panthers and a 34–0 clocking by the Chicago Bears, with their 0 to 108 point differential effectively making the club the worst team in NFL history.

The 1926 Louisville Colonels was one of the worst teams in NFL history, going 0–4 and failing to score a single point.

Their October 17 game with the Detroit Panthers, a 47–0 whitewashing, epitomized the season. On the first play from scrimmage, with just 25 seconds off the clock, the Panthers scored on a scoop-and-score fumble recovery.^[1] "From the time of the first score until the exhibition concluded, the visitors saw their line riddled, their ends circled, and the defense torn to shreds," one local journalist noted.^[1] "So utterly helpless were the Colonels that the Panthers employed every play they knew and turned them into profit in the big parade that netted six touchdowns and a pair of field goals in the 60 minutes of jogging up and down the field."^[1]

The Colonels gained only one first down in the game against Detroit, this coming with a long pass completion at the end of the second period.^[1] They never crossed the midfield stripe during the entire course of the game.^[1]

Note: Tie games were not officially counted in the standings until 1972.