The year 1746 in architecture involved some significant events.

• Mansion of Ledreborg on Zealand, designed by Johan Cornelius Krieger, completed.^[1]
• Asamkirche, Munich, designed by Egid Quirin Asam and Cosmas Damian Asam, completed.
• Old Trinity Cathedral, Saint Petersburg, Russia, completed.
• St Lawrence's Church, Mereworth, England, consecrated.
• Transfiguration Church, Szentendre, Hungary, completed.
• Rebuilding of main chapel of the Cathedral of Évora, Portugal, designed by João Frederico Ludovice, completed.
• Second phase of construction of Poppelsdorf Palace near Bonn completed.
• Foundation stone of new Inveraray Castle in Scotland laid.

• August 3 – James Wyatt, English architect (died 1813)

• May 15 – John James, English architect (born c. 1673)
• June 8 – Giacomo Leoni, Venetian-born architect (born 1686)