Events from the year 1519 in art.

• Girolamo Alibrandi paints the Presentation at the Temple.
• Hans Burckmair paints a panel picture of the Crucifixion, with St. George and the Emperor Heinrich on the wings.
• Albrecht Dürer paints St Anne with the Virgin and Child.
• Sebastiano del Piombo paints The Raising of Lazarus and Portrait of a Man, said to be Christopher Columbus.
• Raffaello Sanzio paints Pope Leo X with Cardinals Giulio de'Medici and Luigi de'Rossi.
• Titian finishes painting The Worship of Venus (Madrid, Museo del Prado).
• Bernard van Orley paints Joris van Zelle.
• Wen Cheng-ming paints Scholars at Leisure in a Precipitous Ravine.
• The portrait of Emperor Maximilian in Nürnberg is painted.

• April 17 - Frans Floris, Flemish historical painter (died 1570)
• date unknown - Pedro de Villegas Marmolejo, Spanish sculptor and painter (died 1596)

• May 2 – Leonardo da Vinci, Italian architect, anatomist, sculptor, engineer, inventor, geometer, scientist, mathematician, musician and painter (born 1452)^[1]
• July 2 - Francesco Bonsignori, Italian painter (born 1455)
• November 30 - Michael Wolgemut, German painter and printmaker (born 1434)
• date unknown
  • Alexander Bening, miniature painter of the Ghent-Bruges school and Netherlandish tradition (born unknown)
  • Domenico Fancelli, Italian sculptor working in Spain (born 1469)
  • Ambrosius Holbein, German and Swiss artist in painting, drawing and printmaking (born 1494)
  • Jan Joest, Dutch painter (born 1450/1460)
  • Antoine Juste, Italian sculptor (born 1479)
  • Juan de Flandes, Early Netherlandish painter who was active in Spain (born 1460)
  • Jan Polack, Polish-born German painter (born 1435)
  • Bartholomäus Zeitblom, German painter and the chief master of the school of Ulm (born 1450)