The year 1505 in science and technology included a number of events, some of which are listed below.

• approx. date – Leonardo da Vinci produces his Codex on the Flight of Birds.^[1]

• Portuguese reach the Comoros archipelago.
• Bermuda is discovered by Spanish explorer Juan de Bermúdez.^[2]
• 1505 or 1506 – Portuguese explorer Gonçalo Álvares is the first to sight what will later be known as Gough Island.

• Scipione del Ferro solves the depressed cubic equation.^[3]

• Ulrich Rülein von Calw publishes Eyn wohlgeordnet und nützlich Büchlein, wie man bergwerk suchen und finden Soll ("A well-ordered and useful little book about how to seek and find mines") in Augsburg, the first scientific treatment of mining in Germany.

• First known reference to a wheellock gun.

• May 20 – Levinus Lemnius, Dutch physician (d. 1568)
• Giovan Battista Bellaso, Italian cryptologist

• Gabriele Zerbi, Veronese gerontologist (b. 1445; sawn in half by disaffected sons of a deceased patient)