Zep or ZEP may refer to:

• Zep (cartoonist) (real name Philippe Chappuis), the creator of comics character Titeuf
• Zep, Inc., cleaning products company
• Zeaxanthin epoxidase
• Jo Jo Zep of Australian band Jo Jo Zep & The Falcons
• Captain Zep – Space Detective, a British children's TV programme
• Led Zeppelin, as a shortened nickname
• Zero Emission Fossil Fuel Power Plants, a European organisation aiming to reduce greenhouse gas emissions
• Zep Solar, manufactures equipment for installing solar panels
• ZEP-RE, Kenyan reinsurance company
• Žep, a mountain in Bosnia and Herzegovina
• Book of Zephaniah, abbreviated Zep. or Zep
• Zep Hindle, character in Saw
• Zep, a regional term for a Submarine sandwich

• Zepp
• Valdis Zeps