William H. Thompson may refer to:

• William Hepworth Thompson (1810–1886), English classical scholar and Master of Trinity College, Cambridge
• William Henry Thompson (1853–1937), U.S. senator from Nebraska
• William Howard Thompson (1871–1928), U.S. senator from Kansas
• William Hale Thompson (1868–1944), mayor of Chicago
• William Harvey Thompson (died 1927), prohibition enforcement agent in the Seattle, Washington
• William H. Thompson (actor) (1852–1923), Scottish-born actor
• William Thompson (Medal of Honor, 1950) (1927–1950), Korean War recipient of the Medal of Honor
• Bill Thompson (Arkansas politician) (died 1981), a state legislator in Arkansas

• William Thompson (disambiguation)