Proto-oncogene Wnt-1, or Proto-oncogene Int-1 homolog is a protein that in humans is encoded by the WNT1 (INT1) gene.[5][6]
The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region.[7]
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Chance PF, Cavalier L, Satran D, Pellegrino JE, Koenig M, Dobyns WB (1999). "Clinical nosologic and genetic aspects of Joubert and related syndromes". J. Child Neurol. 14 (10): 660–666. doi:10.1177/088307389901401007. PMID10511339. S2CID38298436.
Turc-Carel C, Pietrzak E, Kakati S, Kinniburgh AJ, Sandberg AA (1988). "The human int-1 gene is located at chromosome region 12q12-12q13 and is not rearranged in myxoid liposarcoma with t(12;16) (q13;p11)". Oncogene Res. 1 (4): 397–405. PMID3329717.
Gazit A, Yaniv A, Bafico A, Pramila T, Igarashi M, Kitajewski J, Aaronson SA (1999). "Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response". Oncogene. 18 (44): 5959–5966. doi:10.1038/sj.onc.1202985. PMID10557084. S2CID2009505.
Lee CS, Buttitta LA, May NR, Kispert A, Fan CM (2000). "SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm". Development. 127 (1): 109–18. doi:10.1242/dev.127.1.109. PMID10654605.
Tanaka K, Okabayashi K, Asashima M, Perrimon N, Kadowaki T (2000). "The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family". Eur. J. Biochem. 267 (13): 4300–4311. doi:10.1046/j.1432-1033.2000.01478.x. PMID10866835.
Kirikoshi H, Sekihara H, Katoh M (2001). "WNT10A and WNT6, clustered in human chromosome 2q35 region with head-to-tail manner, are strongly coexpressed in SW480 cells". Biochem. Biophys. Res. Commun. 283 (4): 798–805. doi:10.1006/bbrc.2001.4855. PMID11350055.
Mizushima T, Nakagawa H, Kamberov YG, Wilder EL, Klein PS, Rustgi AK (2002). "Wnt-1 but not epidermal growth factor induces beta-catenin/T-cell factor-dependent transcription in esophageal cancer cells". Cancer Res. 62 (1): 277–82. PMID11782388.
