Van Cutsem is a Dutch-language surname originating in Flemish Brabant:^[1]

• Bernard van Cutsem (1916–75), English racehorse breeder and trainer
• Henri Van Cutsem (1839–1904), Belgian patron of the arts
• Hugh van Cutsem (1941–2013), English banker, landowner and horse breeder
• Louis Van Cutsem (1909–1992), Belgian sculptor
• Margaret van Cutsem, otherwise Lady Margaret Fortescue (1923–2013), English landowner and huntswoman
• William van Cutsem, known as William Vance (1935–2018), Belgian comics artist
• William van Cutsem (b. 1979), godfather of Prince George of Wales