Heisenberg's uncertainty principle is a fundamental concept in quantum physics.

Uncertainty principle may also refer to

• Entropic uncertainty, a concept in information theory
• Küpfmüller's uncertainty principle, a concept in electronic engineering formulated by Karl Küpfmüller
• Clinical equipoise, a principle in medical ethics

• The Uncertainty Principle (film), a 2002 Portuguese drama
• The Uncertainty Principle (audio drama), a production based on the British television series Doctor Who
• "The Uncertainty Principle", a season 1 episode of the TV series Joan of Arcadia
• "Uncertainty Principle" (Numbers), a 2005 episode of the TV series Numbers
• "The Uncertainty Principle" (The Spectacular Spider-Man), a 2008 episode of the TV series The Spectacular Spider-Man
• "The Uncertainty Principle", a 2009 episode of the TV series Holby City
• The Uncertainty Principle, a 1978 novel by Dmitri Bilenkin
• Uncertainty Principle, a 2003 novel by Gregorio Morales
• Uncertainty Principle, a British drone/funeral doom metal one-man band

• Uncertainty, a situation involving risky, ambiguous or unknown information