Shome is a Bengali Hindu surname. Notable people with the surname include:

• Chitra Singh (born 1945), born Shome, Indian ghazal singer, also known as Chitra Dutta
• Gautam Shome Sr. (born 1960), Indian cricketer
• Gautam Shome Jr. (born 1963), Indian cricketer
• Mihir Kanti Shome, Indian politician
• Pratibha Basu (1915–2006), born Shome, Bengali writer, also known as Ranu Shome
• Shamit Shome (born 1997), Canadian soccer player
• Sumit Shome (born 1955), Indian cricketer
• Sunit Shome (born 1932), Indian cricketer
• Tillotama Shome, Indian actress
• Title character of Bhuvan Shome

• Shome Panel, Indian government committee