Santos is a Spanish, Portuguese and Galician surname with several variations. The English translation of Santos is Saints. A singular version, Santo, may occur. Origin: Christian, from Latin sanctus.

Other Iberian forms include: De Santo, De Santos, Del Santo, Santi, Santis, Santiz, Senti, Sentis and others. Notable individuals with the surname Santos include:

• Ahmed Santos (newspaper columnist) (born 1974), Mexican newspaper columnist and former boxer
• Alberto Santos-Dumont (1873–1932), Brazilian aviation pioneer
• Alexandre Jose Maria dos Santos (1924-2021), Mozambican Cardinal of the Roman Catholic Church.
• Alfredo M. Santos (1905–1990), Filipino AFP chief of staff
• Altamira Cecília dos Santos (1923-2019), Candomblé high priestess
• Cayetano Santos Godino (1896-1944), Argentine serial killer
• Domitila, Marchioness of Santos (1797–1867), Brazilian noblewoman and the mistress of Emperor Pedro I of Brazil
• Eunice Santos, American computer scientist
• Isabel dos Santos (born 1973), daughter of President of Angola from 1979 to 2017
• José Abad Santos (1886–1942), 5th Justice of the Supreme Court of the Philippines
• Keity Souza Santos, Brazilian immunologist
• Lena Lorraine Santos (1928–2004), American secretary, clubwoman, and civil rights advocate
• Lúcia dos Santos (1907-2005), known as Sister Lúcia of Jesus, Portuguese Roman Catholic Carmelite nun and seer of Our Lady of Fatima
• Lúcio Alberto Pinheiro dos Santos (1889–1950), Portuguese philosopher
• Paulino Santos, (1890–1945), Filipino soldier
• Radleigh Eigen Santos (born 1966), American mathematician, wrote 13 major papers contributing to the study of eigenvalues and eigenvectors, best known for going to underprivileged high schools to spark students' interest in linear algebra and its applications.
• Riza Santos (born 1987), Filipino-Canadian beauty queen
• Rufino Jiao Santos (1908–1973), Filipino Archbishop of Manila and cardinal
• Santos Benavides (1823–1891), American soldier
• Vicente Abad Santos (1916–1993), Justice of the Supreme Court of the Philippines

• Cesar Santos (born 1982) Cuban-American artist and portrait painter
• Emanuele Rodriguez dos Santos (c. 1702–1764) Portuguese-Roman architect
• Jesse Santos (1928–2013), Filipino comics artist

• Antony Santos (born 1967), Dominican Bachata singer/composer
• Anthony "Romeo" Santos (born 1981), Dominican-American songwriter, lead singer, and featured composer of Aventura
• Daniel Santos (singer) (1916–1992), Puerto Rican singer and composer
• Enrique Santos Discépolo (1901–1951), Argentine musician
• Erik Ramos Santos (born 1982), Filipino singer
• Henry Santos Jeter (born 1979), Dominican singer and composer/vocals for Aventura
• Jay Santos, Spanish dance singer
• Joly Braga Santos (1924–1988), Portuguese composer and conductor
• José Manuel Cerqueira Afonso dos Santos (1929–1987), known as Zeca Afonso, Portuguese singer, composer and poet
• Jovino Santos-Neto (born 1954), Brazilian musician
• Lenny Santos (born 1979), Dominican-American guitarist, producer/arranger for Aventura
• Lulu Santos (born 1953), Brazilian singer and guitarist
• Matthew Santos (born 1982), American alternative music singer
• Max Santos (born 1982), Dominican-American bassist for Aventura
• Romeo Santos (born 1981), American singer, songwriter, record producer and actor
• Santos (DJ) (Sante Pucello, born 1971), Italian DJ
• Tony Santos, Spanish funk/R&B singer

• Artur Carlos Maurício Pestana dos Santos (born 1941), known as Pepetela, Angolan writer
• Ary dos Santos (1937–1984), Portuguese poet
• Domingo Santos (1941–2018), Spanish writer
• José dos Santos Ferreira (1919–1993), Portuguese-Macanese writer
• Mayra Santos-Febres (born 1966), Puerto-Rican writer
• Patricia Santos Marcantonio, American fiction writer

• Charo Santos (born 1955), Filipino actress and former president of ABS-CBN Network
• Diana Santos (born 1950), Mexican voice actress
• Gervacio Santos, Filipino film editor
• JC Santos (born 1988), Filipino actor
• Joe Santos (1931–2016), American actor
• Johan Santos (born 1987), Filipino television actor
• Judy Ann Santos (born 1978), Filipino actress
• Lucélia Santos (born 1957), Brazilian actress, director and producer
• María Santos (1899–1949), Argentine actress
• Nelson Pereira dos Santos (1928–2018), Brazilian movie director
• Pablo Santos (1987–2006), Mexican actor
• Rhea Santos (born 1979), Filipino TV news host and journalist
• Roberto Santos (1928–1987), Brazilian film director
• Vilma Santos (born 1953), Filipino actress

• Ahmed Santos (born 1966), Filipino convert to Islam and political militant
• Antonio da Costa Santos (1952-2001), Brazilian architect and politician
• António dos Santos Ramalho Eanes (born 1935), Portuguese general and politician
• Conrad Santos (1934–2016), Canadian politician
• Daiana Santos (politician) (1982-), Brazilian politician
• Délio dos Santos (died 2020), Brazilian politician
• Eduardo Santos Montejo (1888-1974), owned the El Tiempo newspaper, and served as the President of Colombia from August 1938 to August 1942
• Elvin Santos (born 1963), Honduras 2009 presidential candidate
• Farley Santos, American politician from Connecticut
• Fernando da Piedade Dias dos Santos (born 1950), Angolan politician
• Francis E. Santos, CHamoru (Guam) politician
• Francisco R. Santos (1930-93), CHamoru (Guam) politician
• George Santos (born 1988), American politician
• Hélio de Oliveira Santos (born 1950), Brazilian physician and politician
• Isabel Santos (born 1968), Portuguese politician
• José Eduardo dos Santos (1942–2022), Angolan politician and former president of Angola
• José Santos Guardiola (1816–1862), Honduran politician
• José Santos Zelaya (1853–1919), Nicaraguan politician
• Juan Manuel Santos Calderón (born 1951), Colombian president
• Manuel António dos Santos (born 1943), Portuguese politician
• Marcelino dos Santos (1929–2020), Mozambican politician
• Teresita Santos (born 1959), politician from the Northern Mariana Islands

• Cairo Santos (born 1991), Brazilian American football placekicker
• Ricky Santos (born 1984), American Canadian football quarterback
• Todd Santos (born 1964), American footballer

• Alison dos Santos (born 2000), Brazilian runner
• Almir dos Santos (born 1993), Brazilian triple jumper
• Héctor Santos (athlete) (born 1998), Spanish long jumper
• Luíz Antônio dos Santos (born 1964), Brazilian long-distance runner
• Marílson Gomes dos Santos (born 1977), Brazilian distance-runner
• Sueli dos Santos (born 1965), Brazilian javelin thrower

• Gregory Santos (born 1999), Dominican baseball player
• Luis Santos (born 1991), Dominican baseball pitcher
• Omir Santos (born 1981), Puerto Rican baseball player
• Sergio Santos (born 1983), American baseball player
• Victor Irving Santos (born 1976), Dominican-American baseball player

• Arwind Santos (born 1981), Filipino basketball player
• Kelly Santos (born 1979), Brazilian WNBA basketball player
• Rodney Santos (born 1973), Filipino professional basketball player

• Daniel Santos (born 1975), Puerto Rican boxer
• Edgardo Santos (born 1970), Puerto Rican professional boxer
• Manny Santos (1940–2013), Tongan/New Zealand boxer of the 1960s and '70s

• Aderbar Santos (Aderbar Melo dos Santos Neto) (born 1990), Brazilian football goalkeeper
• Adilson dos Santos (born 1976), Brazilian footballer
• Airton Ribeiro Santos (born 1990), Brazilian footballer
• Alejandro de los Santos (1902–1982), Argentine footballer
• Alessandro dos Santos (born 1977), Brazilian-Japanese footballer
• Álvaro Santos (born 1980), Brazilian footballer
• André Bernardes Santos (born 1989), Portuguese midfielder footballer
• André Santos (born 1983), Brazilian footballer
• Andréia dos Santos known as Maycon (born 1977), Brazilian footballer
• Antony Matheus dos Santos (born 2000), Brazilian footballer
• Camila Santos (born 2000), Brazilian footballer
• César Santos (born 1969), Brazilian footballer
• Cristiano Ronaldo dos Santos Aveiro (born 1985), Portuguese footballer
• Djalma Santos (1929–2013), Brazilian footballer
• Eriks Santos (born 1996), Brazilian footballer
• Fausto dos Santos (1905–1939), Brazilian footballer
• Fernando Castro Santos (born 1952), Spanish football manager
• Fernando Santos (born 1980), Brazilian footballer
• Fernando Santos (born 1954), Portuguese footballer and football manager
• Flavio Santos (born 1987), Mexican footballer
• Francileudo Santos (born 1979), Brazilian-born Tunisian footballer
• Georges Santos (born 1970), French-born Cape Verdean footballer
• Giovani dos Santos (born 1989), Mexican footballer
• Héctor Santos (footballer) (1944–2019), Uruguayan footballer
• Jonathan dos Santos (born 1990), Mexican footballer
• Jorge Luis dos Santos (born 1972), Brazilian footballer
• José Mário dos Santos Mourinho Félix, Portuguese football manager
• Leicy Santos, Colombian footballer
• Leslie George Santos, Hong Kong footballer
• Luís Fernando Rodrigues dos Santos (born 1983), Brazilian footballer
• Maicon Santos (born 1984), Brazilian footballer
• Marc Dos Santos (born 1977), Canadian soccer manager
• Marcílio Luís Evangelista dos Santos (born 1964), Brazilian footballer known as Santos
• Marco Aurélio Cunha dos Santos (born 1967), Brazilian footballer
• Neymar da Silva Santos, Jr. (born 1992), Brazilian footballer
• Nílton Santos (1925–2013), Brazilian football player
• Paulo Jorge dos Santos Futre (born 1966), Portuguese footballer
• Rafael Santos Borré, Colombian football player
• Renan dos Santos (born 1989), Brazilian footballer
• Ricardo Izecson dos Santos Leite (born 1982), Brazilian footballer known as "Kaká"
• Ricardo Santos, Brazilian footballer
• Ricardo Santos, Portuguese footballer
• Rony Santos (born 1995), Cape Verdean footballer
• Santos (footballer, born 1983) (Rafael dos Santos Franciscatti), Brazilian football midfielder
• Sergio Santos (born 1994), Brazilian footballer
• Sérgio Santos (born 1998), Portuguese footballer
• Tiago Alencar dos Santos (born 1986), Brazilian footballer
• Toninho dos Santos (born 1965), Brazilian footballer

• Julio Santos (born 1976), Ecuadorian freestyle swimmer
• Maria Santos (born 1978), Portuguese swimmer
• Nicholas Santos (born 1980), Brazilian freestyle swimmer

• Sérgio Santos (born 1975), also known as Serginho or Escadinha, Brazilian volleyball player
• Sidnei dos Santos, Jr. (born 1982), Brazilian volleyball player better known as Sidão
• Yanelis Santos (born 1986), Cuban volleyball player

• Daiane dos Santos (born 1983), Brazilian gymnast
• Iliarde Santos (born 1980), Brazilian mixed martial artist
• Junior dos Santos (born 1984), Brazilian mixed martial artist
• Luís Santos (water polo) (born 1980), Brazilian water polo goalkeeper
• Martin Santos (born 1962), Guam cyclist
• Ricardo Santos, Brazilian beach volleyball player
• Ricardo Santos, Portuguese golfer
• Ricardo Santos, Brazilian windsurfer
• Rodrigo dos Santos (born 1981), Brazilian water polo player
• Ronivaldo Santos Conceição (born 1972), Brazilian squash player

• Santos Family, in the American soap opera Guiding Light
  • Danny Santos
  • Michelle Bauer Santos
• Matt Santos, character on the United States television show The West Wing
• Manny Santos (Degrassi: The Next Generation), character on the Canadian television show Degrassi: The Next Generation
• Nadia Santos, a fictional character in the television series Alias
• In the ABC daytime drama All My Children
  • Julia Santos
  • Mateo Santos
  • Maria Santos
  • Rosa Santos
  • Tageiry Santos
  • Diana Santos
  • Derrica Santos
  • Tiyanna Santos
  • Derrick 'Dee$' Santos
  • Charmaine Santos
  • Ta'Poris Santos
• In the GMA Network daytime drama Abot-Kamay na Pangarap
  • Analyn Santos
  • Lyneth Santos

• Santos (disambiguation)