São Miguel (Portuguese for Saint Michael) is the name of the largest island of the Azores and may also refer to:

• São Miguel, Rio Grande do Norte, a municipality in the State of Rio Grande do Norte
• Barra de São Miguel, Alagoas, a municipality in the State of Alagoas
• Barra de São Miguel, Paraíba, a municipality in the State of Paraíba
• São Miguel do Aleixo, a municipality in the State of Sergipe
• São Miguel do Anta, a municipality in the State of Mina Gerais
• São Miguel do Araguaia, a municipality in the State of Goiás
• São Miguel Arcanjo, Brazil, a municipality in the State of São Paulo
• São Miguel da Baixa Grande, a municipality in the State of Piauí
• São Miguel da Boa Vista, a municipality in the State of Santa Catarina
• São Miguel dos Campos, a municipality in the State of Alagoas
• São Miguel do Fidalgo, a municipality in the State of Piauí
• São Miguel do Gostoso, a municipality in the State of Rio Grande do Norte
• São Miguel do Guamá, a municipality in the State of Pará
• São Miguel do Guaporé, a municipality in the State of Rondônia
• São Miguel do Iguaçu, a municipality in the State of Paraná
• São Miguel das Matas, a municipality in the State of Bahia
• São Miguel dos Milagres, a municipality in the State of Alagoas
• São Miguel das Missões (city), a town in the State of Rio Grande do Sul

• São Miguel das Missões, a Jesuit Mission and UNESCO Heritage Site near the city of the same name

• São Miguel do Oeste, a municipality in the State of Santa Catarina
• São Miguel do Passa Quatro, a municipality in the State of Goiás
• Subprefecture of São Miguel Paulista, São Paulo
• São Miguel Paulista (district of São Paulo), a district in the subprefecture of the same name in the city of São Paulo, Brazil
• São Miguel de Taipu, a municipality in the State of Paraíba
• São Miguel do Tapuio, a municipality in the State of Piauí
• São Miguel do Tocantins, a municipality in the State of Tocantins

• São Miguel, Cape Verde, a municipality on the island of Santiago

• São Miguel do Mato (Arouca), a civil parish in the municipality of Arouca
• São Miguel do Rio Torto, a civil parish in the municipality of Abrantes
• Sobral de São Miguel, a civil parish in the municipality of Covilhã
• São Miguel (Lisbon), a civil parish in the municipality of Lisbon
• São Miguel (Penela), a civil parish in the municipality of Penela
• São Miguel do Mato (Vouzela), a civil parish in the municipality of Vouzela
• An alternative name for the civil parish of Vilar de Perdizes in the municipality of Montalegre

In the archipelago of the Azores

• São Miguel Island, located in the Eastern Group, and largest island
• São Miguel (Vila Franca do Campo), a civil parish in the municipality of Vila Franca do Campo, island of São Miguel

• The carrack Bérrio, part of the Portuguese explorer, Vasco da Gama's fleet