Polidori is an Italian surname. Polidori may refer to:

• Alessandro Polidori (born 1992), Italian footballer
• Ambra Polidori (born 1954), Mexican artist
• Enzo Polidori (1936–2021), Italian politician
• Erika Polidori (born 1992), Canadian softball player
• Frances Polidori (1800–1886), daughter of Gaetano, mother of Maria, Dante, William and Christina Rossetti
• Gaetano Polidori (1763–1853), Italian writer
• Giancarlo Polidori (born 1943), Italian cyclist
• Gianni Polidori (1923–1992), Italian art director
• Gino Polidori (1941–2014), American politician
• John William Polidori (1795–1821), Italian-English physician and writer, son of Gaetano
• Paolo Polidori (1778–1847), Italian cardinal
• Robert Polidori (born 1951), Canadian photographer
• Victor Polidori (1888–1931), French gymnast

• Polidori Sausage, a food company
• Polidori RLA, a historical name for the now defunct Air Estates Airport

• Polydore (disambiguation)