Pedrini is an Italian surname. Notable people with the surname include:

• Daniele Pedrini (born 1976), Italian ski mountaineer
• Domenico Pedrini (1728–1800), Italian painter
• Enrico Pedrini (1940–2012), Italian academic, theorist and art collector
• Filippo Pedrini (1763–1856), Italian painter
• Matteo Pedrini (born 2000), Italian footballer
• Teodorico Pedrini (1671–1746), Italian Vincentian priest, missionary, musician, and composer