Paoletti is an Italian surname. Notable people with the surname include:

• Antonio Ermolao Paoletti (1834–1912), Italian painter
• Arturo Paoletti, Italian boxer
• Christian Paoletti (born 1984), Italian footballer
• Enzo Paoletti, Italian scientist
• Gabriele Paoletti (born 1978), Italian footballer
• Luigi Paoletti Vinea, 19th-century Italian painter
• Pietro Paolétti (1801–1847), Italian painter and engraver
• Roland Paoletti (1931–2013), British-Italian architect