MPG or mpg may refer to:

• .mpg, one of a number of file extensions for MPEG-1 or MPEG-2 audio and video compression
• MPG (gene), a human gene coding for N-methylpurine DNA glycosylase
• M.P.G., a 1969 album by Marvin Gaye
• Manual pulse generator, a device normally associated with numerically controlled machinery
• Mark-Paul Gosselaar, American actor
• Matías Pérez García (born 1984), Argentine footballer
• Max-Planck-Gesellschaft (Max Planck Society), a German non-profit research organization
• Media Planning Group, former name of Havas Media, a media division of Havas
• Miles per gallon, a measurement of fuel economy in automobiles, boats and other motorized vehicles
• Milford Proving Ground, one of several General Motors Proving Grounds
• Minutes per game in basketball
• Monopotassium glutamate, a flavor enhancer
• Motor Press Guild, a non-profit association for professionals within the motoring press
• Multiplayer game
• Multiplayer video game
• Multi-touch, physics and gestures, a type of computer touch screen
• Music Producers Guild, an association of music producers in the United Kingdom
• MPG: Motion Picture Genocide, 1997 film