Lesego is a given name. Notable people with the name include:

• Lesego Makhubela (born 1986), South African politician
• Lesego Makgothi (born 1965), Mosotho polician
• Lesego Motsepe (1974–2014), South African actress
• Lesego Motsumi (1955/56-2023), Motswana politician
• Lesego Nkoane, South African soccer player
• Lesego Semenya (1982–2021), South African chef and author
• Lesego Senokwane (born 1997), South African cricketer
• Lesego Rampolokeng (born 1965), South African poet
• Lesego Tlhabi (born 1988), South African comedian