Latrobe or La Trobe may refer to:

• Benjamin Henry Latrobe (1764–1820), architect of the United States Capitol, brother of C. I. Latrobe
• Benjamin Henry Latrobe II (1806–1878), (or sometimes "Jr."), an engineer, son of B. H. Latrobe
• Charles La Trobe (1801–1875), first lieutenant-governor of Victoria, Australia, son of C. I. Latrobe
• Charles Hazlehurst Latrobe, (1833–1902), engineer, bridge-builder, architect, son of B. H. Latrobe II
• Christian Ignatius Latrobe (1758–1836), English clergyman and musician
• Ferdinand Claiborne Latrobe (1833–1911), seven-time mayor of Baltimore, son of John H. B. Latrobe
• Henry Sellon Latrobe (1792–1817), architect, eldest son of B. H. Latrobe
• John H. B. Latrobe (1803–1891), writer, lawyer, historian, artist, inventor, civic activist, son of B. H. Latrobe

• City of Latrobe, Victoria
• Latrobe River, West Gippsland, Victoria
• Latrobe Valley, Gippsland, Victoria
• Mount LaTrobe, Wilsons Promontory, Victoria
• Latrobe, Tasmania, a town
• Division of La Trobe, Victoria, an electoral division
• La Trobe Street, Melbourne

• Latrobe, California, an unincorporated community
• Latrobe, Pennsylvania, a city
• Latrobe, West Virginia, an unincorporated community and coal town
• Latrobe Park, Baltimore, a public park in Locust Point, Maryland

• Banksia Latrobe Secondary College, Heidelberg West, Victoria, Australia
• Charles La Trobe College, Macleod, Victoria, Australia
• La Trobe University, Victoria, Australia
  • La Trobe University College of Northern Victoria, Bendigo

• Latrobe Football Club of Latrobe, Tasmania
• Latrobe Athletic Association of Latrobe, Pennsylvania, from 1895 to 1909, one of the earliest professional American football teams
• Latrobe (horse), thoroughbred racehorse, winner of the 2018 Irish Derby

• HMAS Latrobe, a Royal Australian Navy corvette
• Latrobe Brewing Company in Latrobe, Pennsylvania
• Latrobe Stove, a cast-iron stove for home or room heating invented in the early 1800s
• The La Trobe Journal, a scholarly journal of the State Library Victoria, Australia