Higbee may refer to:

• Higbee, Missouri, a city in Randolph County, Missouri, in the United States
• Higbee's, a former Cleveland, Ohio, department store
• USS Higbee (DD-806), a United States Navy destroyer in commission from 1945 to 1979
• Higbee cut, a specific cut added to a screw thread to produce a blunt start

• Chauncey L. Higbee (1821–1884), early member of the Latter Day Saints Movement
• Edward Young Higbee (1810–1871), Episcopal clergyman
• Elias Higbee (1795–1843), American historian and recorder in the Church of Jesus Christ of Latter Day Saints
• Ethan Higbee, American filmmaker
• Francis M. Higbee (1820–1856), early member of the Latter Day Saints Movement
• Lenah Higbee (1874–1941), pioneering nurse in the United States Navy
• Mahlon Higbee (1901–1968), American baseball player
• Shawn Higbee (born 1970), American professional motorcycle racer
• Tyler Higbee (born 1993), American football tight end

• Kirby Higbe