Great Famine may refer to:

• Great Chinese Famine (1958–1961)

• Great Famine (Greece) (1941–1944)

• Great Bengal famine of 1770
• Great Rajputana Famine (1869)
• Great Famine of 1876–1878

• Great Famine (Ireland) (1845–1852)

• Kan'ei Great Famine (1640–1643)
• Great Tenmei famine (1782–1788)
• Tenpō famine or Great Tenpō famine (1833–1837)

• Great Famine of Mount Lebanon (1915–1918)

• North Korean famine (1994–1998)

• Great Famine of 1315–1317
• Great Famine of 1695–1697

• Holodomor or the Great Famine of 1932–1933

• The Great Famine, a 2011 documentary about the Russian famine of 1921

• Droughts and famines in Russia and the Soviet Union
• List of famines