Damascene may refer to:

• Topics directly associated with the city of Damascus in Syria:
  • A native or inhabitant of Damascus
  • Damascus Arabic, the local dialect of Damascus
  • Damascus steel, developed for swordmaking
  • "Damascene moment", the religious conversion of Paul
• Animal breeds:
  • Damascene (pigeon)
  • Damascus goat
• John of Damascus (c. 676-749), Syrian Christian monk and priest
• Materials technologies evoking the visual texture of Damascus steel:
  • Damascening, of inlaying different metals into one another
  • Damask, a reversible figured fabric
  • Damascene patterning, a manufacturing process used to pattern copper into microchips