CRE or cre may refer to:

• Campaign for Real Education, a British educational advocacy group
• Castle Rock Entertainment, an American film and television production company
• Center for Regulatory Effectiveness, an American lobbying firm
• China Railway Express Company, a parcel and cargo shipping arm of China Railway
• Commission de régulation de l'énergie, the French energy regulator
• Commission for Racial Equality, a former British government body
• Cumann Rothaíochta na hÉireann (Cycling Ireland), an Irish national cycling organization

• cAMP response element, a type of DNA sequence bound to by CREB
• Carbapenem-resistant enterobacteriaceae, an antibiotic-resistant bacteria family
• Certified Reliability Engineer, an American Society for Quality (ASQ) certification
• Chemical reaction engineering, chemical engineering or industrial chemistry dealing with chemical reactors
• Cis-acting replication element, a component of many RNA viruses
• Cis-regulatory element, regions of non-coding DNA which regulate the transcription of neighboring genes
• Cre recombinase, an enzyme that catalyzes a type of site-specific homologous recombination
• I-CreI, a homing endonuclease

• CRE, LRT station abbreviation for Coral Edge LRT station, Singapore
• CRE, National Railway station code for Crewe railway station, Cheshire, England
• CRE, airport code for Grand Strand Airport near North Myrtle Beach, South Carolina, U.S.

• Camp Rock Enon, a Boy Scout camp in Virginia
• Commander, Royal Engineers, the senior Royal Engineers officer in a British Army division, usually a lieutenant-colonel
• Commercial real estate, see Commercial property
• Common Recruitment Examination, an examination for recruiting civil servants in Hong Kong
• Corporate real estate, real property held or used by a business enterprise or organization for its own operational purposes