CORE may refer to:

• Canadian Ombudsperson for Responsible Enterprise
• Center for Operations Research and Econometrics at the University of Louvain (UCLouvain) in Belgium
• Center for Organizational Research and Education, an American non-profit entity
• CORE (research service), a research service at The Open University in Buckinghamshire, England
• Central Organisation for Railway Electrification, a subsidiary of Indian Railways
• Congress of Racial Equality (CORE), an African-American civil rights organization in the United States
• Coordenadoria de Recursos Especiais (Brazil), a SWAT unit
• Committee on Operating Rules for Information Exchange, part of the Council for Affordable Quality Healthcare
• Caucus of Rand File Educators, a caucus of the Chicago Teachers Union
• Intel Core, stylized and marketed as Intel CORE as of 2009
• Lutheran CORE, or Coalition for Renewal, a non-profit organization formed in 2005
• CORE Project (Curriculum Open-Access Resources in Economics Project)
• CORE (Clinical Outcomes in Routine Use) System and CORE System Trust, see CORE-OM
• The CORE, an area (the last subarea of Hotland) in the video game Undertale
• "CORE", a track from the soundtrack of the 2015 video game Undertale by Toby Fox
• Collective Oregon Eateries, Portland, Oregon, U.S.
• CORE (Community Organized Relief Effort), Non-profit organization founded by Sean Penn and Ann Lee