CDH may refer to:

• CDH Investments, a Chinese asset management firm
• Central DuPage Hospital, Illinois, U.S.A.
• Centre Démocrate Humaniste, a Belgian political party
• Cloudera's Distribution including Apache Hadoop
• The Computational Diffie-Hellman assumption, that a certain mathematical problem is hard
• Congenital diaphragmatic hernia
• Cretin-Derham Hall, school in St. Paul, Minnesota, U.S.A.
• Cellobiose dehydrogenase, a plant enzyme