Brutus is a Latin surname, which usually refers to Marcus Junius Brutus (85–42 BC), one of the assassins of the Roman dictator Julius Caesar.

Brutus may also refer to:

• Lucius Junius Brutus, putative founder of the Roman Republic
• Marcus Junius Brutus (tribune 83 BC), father of the homonymous tyrannicide
• Marcus Junius Brutus, Julius Caesar's most famous assassin, usually the one referred to in literature and art
• Decimus Junius Brutus Albinus, another of Caesar's assassins
• Junius Brutus (disambiguation), others with similar names

• Brutus of Troy, legendary founder of Britain
• Brutus Greenshield, Brutus II
• Brutus (Antifederalist), author of several Anti-Federalist Papers
• Brutus Babington, 1558–1611, Irish bishop
• Brutus Beefcake, stage name of professional wrestler Edward Leslie
• Brutus (rapper), Dutch rapper
• Junius Brutus, pseudonym of Charles Blount (deist) (1654–1693)
• Brutus, pseudonym of Lucien Bonaparte during the French Revolution
• Roman Czerniawski or Brutus (1910–1985), World War II double agent

• Bluto or Brutus, a cartoon character from "Popeye"
• Brutus, a character in Anima: Age of the Robots
• Brutus, a character in Human Killing Machine
• Brutus, a character in The Hunger Games
• Brutus, a character in The Rescuers
• Brutus, a character in Race for Your Life, Charlie Brown
• Brutus, an unlockable character in the Chapter 2, Season 2 Battle Pass in Fortnite Battle Royale

• Brutus, Łódź Voivodeship, in central Poland
• Brutus, Michigan, unincorporated community in Emmet County, Michigan, United States
• Brutus, New York, a town in Cayuga County, New York, United States

• Brutus (Canadian band), a 1970s Canadian band
• Brutus (Czech band), a Czech rock band
• Brutus (Norwegian band), a Norwegian blues rock band
• Brutus (Belgian band), a Belgian post-hardcore band
• Brutus (album)

• Brutus (car), an aero-engined car
• Texan schooner Brutus, a ship in the Texas Navy
• Brutus, a South Devon Railway Dido-class steam locomotives

• Brutus (Cicero), an oratory by Cicero
• Brutus (magazine), a Japanese magazine
• Brutus (sculpture), a sculpture by Michelangelo
• Brutus (tragedy), a 1730 play by Voltaire
• Brutus (play), an 1818 play by John Howard Payne
• Brutus (1911 film), an Italian film
• Brutus (2016 film)
• Brutus, or The Lictors Bring to Brutus the Bodies of His Sons, a painting by Jacques-Louis David
• Brutus, a character in Shakespeare's Julius Caesar
• Brutus, or The Fall of Tarquin, a play by John Howard Payne

• Dennis Brutus (1924–2009), South African poet
• Joel Brutus (born 1974), Haitian judoka

• Brutus Buckeye, the athletics mascot of Ohio State University
• Brutus cluster, a high-performance cluster at ETH Zurich
• Brutus Jeans, maker of denim apparel in the 1970s and '80s