Brian James may refer to:

• Brian James (soccer) (born 1993), American soccer player
• Brian James (guitarist) (born 1955), British punk guitarist, founding member of the Damned
• Brian Girard James, better known as Road Dogg (born 1969), American professional wrestler
• Brian James (rugby league) (1943–2020), Australian rugby league footballer
• Brian James (actor) (1918–2009), Australian actor
• Brian James (basketball) (born 1956), American basketball coach
• Brian James (cricketer, born 1934) (1934–2000), English cricketer
• Brian James (cricketer, born 1941) (1941–2002), English cricketer
• Brian James (cricketer, born 1982), Zimbabwean cricketer
• Brian d'Arcy James (born 1968), American actor and musician
• Brian R. James (born 1974), American game designer and software engineer
• Brian James (priest) (1930–2013), Church in Wales priest

• Brion James (1945–1999), American actor