American Son may refer to:

• American Son (2008 film), a drama film starring Nick Cannon
• American Son (2019 film), a drama film starring Kerry Washington
• American Son (album), an album by Levon Helm
• American Son, an album by Tim Rose
• American Son, an album by Tom Breiding
• American Son, an autobiography by Oscar De La Hoya
• An American Son: A Memoir, an autobiography by Marco Rubio
• American Sons, a 1994 film by Steven Okazaki
• American Son, a fictional powered armor and alias used by Harry Osborn in Marvel Comics