Afa or AFA may refer to:

• Air force academy
• Air Force Academy, Colorado, a locality occupied by the U.S. Air Force Academy
• United States Air Force Academy
• Air Force Association
• American Flyers Airline
• Association of Flight Attendants
• Brazilian Air Force Academy (Portuguese: Academia da Força Aérea)
• San Rafael Airport (Argentina) in Mendoza Province, Argentina, by IATA code
• Portuguese Air Force Academy (Portuguese: Academia da Força Aérea)

• Afa, Corse-du-Sud, a commune in Corsica
• Afghani (currency), the currency of Afghanistan
• Agence française anticorruption, the French Anti-Corruption Agency
• Alberta Foundation for the Arts, arts funding body of Alberta, Canada
• Andorran Financial Authority, the financial regulator of Andorra

• Anime Festival Asia, annual ACG event in Southeast Asian countries
• Anthology Film Archives, a film archive and theater
• ARY Film Awards, a Pakistani Film Awarding Ceremony

• Afá, a West African religion, also known as Ifá in some languages
• Afa (mythology), in the Polynesian mythology of Samoa

• Argentine Football Association

• Aborigines' Friends' Association
• Atheist Foundation of Australia
• Australian Family Association

• Academic Forum for Foreign Affairs
• Austrian Football Association

• Trâ Armânami Association of French Aromanians, or Association des Français Aroumains in French

• Accumulatoren-Fabrik AFA
• Agentur für Arbeit
• Antifaschistische Aktion

• Antifascistisk aktion

• Agriculture and Food Agency

• Amateur Fencing Association, former name of British Fencing Association
• Amateur Football Alliance, formerly Amateur Football Association
• Anti-Fascist Action
• Atrial Fibrillation Association
• Associate Financial Accountant in the Institute of Financial Accountants
• Approved Franchise Association, one of three trade associations for the UK franchising industry.

• Admiral Farragut Academy

• American Football Association (1884–1924), first organization for association football (soccer) in the U.S.
• American Football Association (1978–1983), a minor professional gridiron football league
• Arena Football Association, a minor professional indoor gridiron football league

• Ad Fontes Academy
• Advertising Federation of America
• American Family Association
• American Farrier's Association
• American Federation of Arts
• American Federation of Astrologers
• American Finance Association
• American Forensics Association
• American Forestry Association
• American Freedom Agenda
• Arkansas Fire Academy
• Asatru Folk Assembly, formerly Asatru Free Assembly

• Asian Farmers' Association for Sustainable Rural Development

• Afa Anoaʻi Jr. (born 1984), American professional wrestler
• Afa Anoaʻi (1942–2024), Samoan-American professional wrestler

• Afa, a diminutive of the Russian female first name Aviafa
• AFA, an all-flash array in computing.
• AFA (automobile), a Spanish automobile
• Afro-Asiatic languages (ISO 639-3 code)
• Alternating finite automaton, in computer science
• Amfonelic acid, a stimulant and hallucinogen
• Anti-Foundation Axiom, a mathematical axiom
• Aphanizomenon flos-aquae, an edible blue-green algae
• Asian Film Awards, an annual Hong Kong award